Transdermal Systems  (Automated)



LOGAN SYSTEM 913-12 Automated Transdermal Diffusion Cell Sampling System



Features
  • Takes samples from 12 bubble free cells for up to 20 sampling time points
  • Open air system, no pressure build up during the test, no leak system
  • Syringe pump sampling system accuracy of ±1%
  • Sampling takes place before media replacement to avoid sample dilution
  • Printer for full report
The Logan System 913-12 is designed to save valuable time by delivering precise transdermal samples into HPLC vials or sample tubes automatically. The membrane is mounted between the cell cap (donor) and the cell body (receptor). The membrane is bathed from below by an isotonic saline solution. Temperature is maintained at 32° or 37°C by thermostatically controlled water which enters the lower port of the water jacket surrounding the saline solution chamber and circulates out through the upper port. Water is supplied and removed by two (upper and lower) stainless steel manifolds connected to a constant temperature bath.

Homogenous distribution of temperature in the saline bathing solution is accomplished by the agitating motion of a Teflon-covered magnetic stirring bar, driven by an external magnet mounted on a timing- motor. The cell cap is open to the air, exposing the membrane’s upper surface to ambient conditions. The open cap also allows for a finite dose application of the compound being studied.
The SYP Series Syringe Pump Module withdraws & measures sample volumes from the transdermal diffusion cells at each time interval. Individual samples are dispensed simultaneously into HPLC vials that are stored in the SCR Series Sample Collectors. To avoid sample dilution, the replacement media takes place right after each sampling. The lift plate tilts all Franz cells to allow all the air bubbles to purge out of the cells while doing the media replacement. This will insure that there is no air bubbles under the skin/patch; the tilted plate goes back to the horizontal position once the media replacement is complete and continues the test.

Specifications

FDC-6T Diffusion Cell Drive Console X 2 w/ VTC-300 Heater Circulator
  • Cell positions.........................6
  • Control zones........................2
  • Zone 1.........................1, 2, 3
  • Zone 2..........................4, 5, 6
  • Speed.................................500 RPM at 50 Hz/600 RPM at 60 Hz
  • Stirring...............................Teflon-coated magnetic bar
  • Temperature control................25°C to 45°C ±1°C
  • Heater................................ 700 watt
  • Voltage..............................110V/120V 50/60Hz or 220V/140V 50/60Hz
SYP-6L2B-10ML Syringe Pump X 2
  • High torque motor driven with encoder feedback loop
  • Controls up to (6) 10 ml syringes
  • Syringe accuracy: ±1% for transfer volume more than 1 ml
  • Maximum transfer volume: 10 ml (as per stroke)
  • Minimum transfer volume: .5 ml (as per stroke)
  • 110/220 Volts, 50/60 Hz
  • Size: 15” X 13” X 20”
SCR–DL Sample Collector
  • Tray A: 240 position collection for 16mm DIA sample tubes (150mm max)
  • Tray B: 240 position collection for Agilent/Shimadzu HPLC vials
  • 12 samples per time point, 20 time points.
  • Built-in replacement media reservoir
  • Size: 19” X 22” X 19”
DSC-800 System Controller
  • Controls the drive consoles, the transfer pump and sampler collector
  • Sampling intervals within 4 minutes
  • Touch panel with color display
  • Link up with printer
  • Supply with support rack
  • 110/220 Volts , 50/60 Hz
  • Size: 6” X 6” X 10”
DEAR-0012 Degassing Station (optional)
  • Vacuum 25in-Hg
  • Power 900 watts
  • Manual or PLC control




LOGAN SYSTEM 914-12 Automated Transdermal (Dry Heat) Sampling System



Features
  • Takes samples from 12 bubble free cells for up to 20 sampling time points
  • Open air system, no pressure build up during the test, no leak system
  • Syringe pump sampling system accuracy of ±1%
  • Sampling takes place before media replacement to avoid sample dilution
  • Printer for full report
The Logan System 914-12 is designed to save valuable time by delivering precise transdermal samples into HPLC vials or sample tubes automatically. The DHC-6AT Dry Heat Transdermal Drive Console is remarkably simple to use, 6 DHBFC (Dry-Heat Bubble Free Cells) are surrounded by a thermostatically controlled heater block, where temperature is maintained at 32° or 37°C. DHBF Cells are constructed with molded Teflon donors and precision cut glass bodies. Skin is mounted between the cell cap (donor) and the cell body (receptor). The dermis is bathed from below with an isotonic saline solution injected through the bottom port, which flows thru the upper port to provide contact with no bubbles under the skin membrane.

Homogenous distribution of temperature in the saline bathing solution is accomplished by the agitating motion of a Teflon-covered magnetic stirring bar, driven by an external magnet mounted on a timing- motor. The cell cap is open to the air, exposing the membrane’s upper surface to ambient conditions. The open cap also allows for a finite dose application of the compound being studied.

The SYP Series Syringe Pump Module withdraws & measures sample volumes from the transdermal diffusion cells at each time interval. Individual samples are dispensed simultaneously into HPLC vials that are stored in the SCR Series Sample Collectors. To avoid sample dilution, the replacement media takes place right after each sampling. The lift plate tilts all Dry Heat Franz Cells to allow all the air bubbles to purge out of the cells while doing media replacement. This will insure that there is no air bubbles under the skin/patch; the tilted plate goes back to the horizontal position once the media replacement is complete and continues the test.

Specifications


DHC-6AT DRY HEAT Diffusion Cell Drive Console X 2
  • Cell positions.........................6
  • Control zones........................2
  • Zone 1.........................1, 2, 3
  • Zone 2..........................4, 5, 6
  • Speed.................................500 RPM at 50 Hz/600 RPM at 60 Hz
  • Stirring...............................Teflon-coated magnetic bar
  • Temperature control................25°C to 45°C ±1°C
  • Heater................................ 150 watt
  • Voltage..............................110V/120V 50/60Hz or 220V/140V 50/60Hz
SYP-6L2B-10ML Syringe Pump X 2
  • High torque motor driven with encoder feedback loop
  • Controls up to (6) 10 ml syringes
  • Syringe accuracy: ±1% for transfer volume more than 1 ml
  • Maximum transfer volume: 10 ml (as per stroke)
  • Minimum transfer volume: .5 ml (as per stroke)
  • 110/220 Volts, 50/60 Hz
  • Size: 15” X 13” X 20”
SCR–DL Sample Collector
  • Tray A: 240 position collection for 16mm DIA sample tubes (150mm max)
  • Tray B: 240 position collection for Agilent/Shimadzu HPLC vials
  • 12 samples per time point, 20 time points.
  • Built-in replacement media reservoir
  • Size: 19” X 22” X 19”
DSC-800 System Controller
  • Controls the drive consoles, the transfer pump and sampler collector
  • Sampling intervals within 4 minutes
  • Touch panel with color display
  • Link up with printer
  • Supply with support rack
  • 110/220 Volts , 50/60 Hz
  • Size: 6” X 6” X 10”
DEAR-0012 Degassing Station (optional)
  • Vacuum 25in-Hg
  • Power 900 watts
  • Manual or PLC control


 
 
 
 
PT. SPEKTRA SURYA UTAMA
 
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